wizyta

od 2020-09-20

Title: Assessment of polydopamine coated magnetic nanoparticles in doxorubicin delivery

Source: RSC Advances

Year : 2016

Abstract:

Magnetic nanoparticles (MNP) coated with bioinspired polydopamine (PDA) were obtained via a co-precipitation method and oxidative polymerization of dopamine. Nanoparticles were investigated by FTIR, TEM and SQUID. Loading capacity of anticancer drug doxorubicin was determined by UV-Vis spectroscopy. The nanocomposites exhibit a high drug loading capacity of 0.46 mg mg(-1). Anticancer activity of the nanocomposites was proved in profound in vitro tests on HeLa cells. Cytotoxicity and internalization of nanoparticles were checked using various method, i.e. proliferation assay (WST-1), a two-colour fluorescence cell viability assay, and fluorescent and confocal microscopy.

DOI: 10.1039/c5ra24222c   (Pobrane:  aktualizowanie)