wizyta

od 2020-09-20

Title: Identification of multiple sclerosis cerebrospinal fluid biomarkers using nuclear magnetic resonance spectroscopy

Source: Multiple Sclerosis Journal

Year : 2014

Abstract:

Nuclear Magnetic Resonance (NMR) spectroscopy identifies metabolites of small molecular weight present in cerebrospinal fluid (CSF). Diagnosis of multiple sclerosis (MS) and clinically isolated syndrome (CIS) is based on a combination of symptoms, laboratory tests and MRI results, and sometimes is not conclusive especially early in the disease process. Previous studies that employed NMR to examine the CSF of patients with CIS and MS focused mainly on differences and did not use receiver operator characteristics (ROC) curves statistics to assess the peaks. Additionaly they usually involved sample pH adjustment that could influence the metabolites and their stability.

DOI: 10.1177/1352458514546077   (Pobrane:  2018-04-04)