wizyta

od 2020-09-20

Title: The radiolytic studies of cefpirome sulfate in the solid state

Source: Journal of Pharmaceutical and Biomedical Analysis

Year : 2016

Abstract:

The possibility of applying radiation sterilization to cefpirome sulfate was investigated. The lack of changes in the chemical structure of cefpirome sulfate irradiated with a dose of 25 kGy, required to attain sterility, was confirmed by UV, FT-IR, Raman, DSC and chromatographic methods. Some radical defects with concentration no more than over a several dozen ppm were created by radiation. The antibacterial activity of cefpirome sulfate for two Gram-positive and three Gram-negative strains was changed. The radiation sterilised cefpirome sulfate was not in vitro cytotoxic against fibroblast cells.

DOI: 10.1016/j.jpba.2015.11.008   (Pobrane:  aktualizowanie)