wizyta

od 2020-09-20

Title: Dynamical properties of nimodipine molecules confined in SBA-15 matrix

Source: Chemical Physics

Year : 2016

Abstract:

The paper reports results of C-13 and H-1 ssNMR for nimodipine confined in mesopores of SBA-15 for the samples (i) containing nimodipine molecules inside and on the external surface of silica, (ii) containing nimodipine only inside pores forming an incomplete monolayer on the surface (iii) for bulk nimodipine. The measurements permitted comparison of the dynamics of nimodipine bulk and confined in pores. The confined nimodipine is in an amorphous state and has additional degrees of rotational freedom with respect to the bulk one. The height of the energy barrier related to the rotation of methyl groups in confined nimodipine is lower than in bulk nimodipine. The higher mobility of nimodipine molecules confined in silica pores can explain the higher release rate of nimodipine from silica matrix than dissolution rate of bulk drug.

DOI: 10.1016/j.chemphys.2016.06.020   (Pobrane:  aktualizowanie)