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wizyta

od 2020-09-20


Authors: Kristinaityte K., Zalewski T., Kempka M., Sakirzanovas S., Baziulyte-Paulaviciene D., Jurga S., Rotomskis R., Valeviciene N.R.

Title: Spin-lattice relaxation and diffusion processes in aqueous solutions of gadolinium-based upconverting nanoparticles at different magnetic fields

Source: Applied Magnetic Resonance

Year : 2019


Abstract:

We investigated the influence of gadolinium (Gd)-based upconverting nanoparticles (UCNPs) on water spin-lattice relaxation (T-1) and diffusion at different magnetic field strengths (0.4T and 9.4T). Our findings show that smaller NPs (12nm compared to 19nm) were more favourable for proton relaxivity. We also demonstrate that using simplified Solomon-Bloembergen-Morgan (SBM) model we can associate two measured diffusion coefficients with processes occurring near the surface of UCNPs and in bulk water. Using the relationship between relaxation and diffusion, we can estimate not only the total impact of NPs on relaxation of water molecules, but also the impact on relaxation of local water molecules, directly connected to paramagnetic Gd3+ ions in NPs. Different magnetic field strengths did not alter the spin-lattice relaxivity of NPs. This suggests that Gd-based UCNPs could be developed into high-performance multimodal magnetic resonance imaging contrast agents working over a broad range of imaging field strengths used in clinical routine.

DOI: 10.1007/s00723-018-1105-z   (Pobrane:  2020-12-28)

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