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wizyta

od 2020-09-20

Mgr Augustyn Moliński  | 2019-10 - obecnie

doktorant

   WF UAM pokój: 131      +48 61-829-5030       augmol@amu.edu.pl


Publikacje                          Seminaria


2.

Moliński A., Zaręba J., Iżykowska J., Skupin M., Andrzejewska W., Jurga S., Kozak M.

Abstrakt lub materiały konferencyjne, albo abstrakt publikacji
z dodatkowymi numerami DOI

C-60 fullerenes as contrast agents - structural, spectroscopic and nano-toxicity studies Recently, C60 fullerenes have been proposed as contrast agents for MRI method [1]. Especially promising for in vitro and in vivo NMR imaging are their complexes with gadolinum (containing Gd3+ ions entrapped inside the fullerene cage) known also as gadofullerenes [2]. The general problem of carbon nanomaterials is their toxicity towards living cells [3]. The aim of our study is to devise fullerene-based suspensions characterized with low toxicity, which could later be developed into metallofullerene contrast agents. We want to achieve that goal using C60 fullerenes, pluronics to lower the toxicity and phosphatidylcholine derivatives (DMPC or DPPC) to enhance biocompatibility of fullerenes and to stimulate the cellular absorption. In this work we would like to present results of toxicity studies of C60 fullerene systems pluronic modified C60 fullerene systems towards HeLa cells, along with results of structural analyses by AFM and SEM microscopies, FTIR and SAXS. This study was supported by Ministry of Science and Higher Education (Poland), within the project, Najlepsi z najlepszych!”

Biophysical Journal, 112(3) S1, 593A (2017)

DOI: 10.1016/j.bpj.2016.11.3191   (Pobrane:  2020-11-05)


1.

Zaręba J., Iżykowska J., Skupin M., Moliński A., Dobies M., Jurga S., Kozak M.

Abstrakt lub materiały konferencyjne, albo abstrakt publikacji
z dodatkowymi numerami DOI

The influence of surfactant structure and geometry on nanotoxicity and dispersion of carbon nanotubes Graphene, nanotubes and fullerenes, also known as carbon nanomaterials (CN), because of the their unique properties have potential applications not only in preparation of new composite materials or in electronics, but they can be also components of drug delivery systems. However, the applications of CN in life sciences or biomedicine require stable dispersions of these materials in water. The hydrophobic nature of CN causes serious problems with their separation in water solutions. Our study is aimed to find a way of dispersing such CN systems in water, by the use of non-covalent surface modification via different surfactants. In this work we focused on the use of trimeric, dimeric and monomeric surfactants fornon-covalent surface modification of selected carbon nanotubes. The toxicity of these systems (aqueous solutions of CN with surfactants and surfactants solutions) towards selected cell cultures (e. g. HeLa cells) was also tested. The surfactants studied can interact with carbon nanotubes in a number of different modes: hydrophobic interactions (surfactant chains with CN side walls) or π-π interactions (aromatic rings of surfactants with CN surface). Infrared spectroscopy and atomic force microscopy were used for characterization of the systems studied. Finally, we focused on mechanical properties of cells exposed to surfactants and CN. This study was supported by the Ministry of Science and Higher Education (Poland), within the project “

Biophysical Journal, 112(3) S1, 156A (2017)

DOI: 10.1016/j.bpj.2016.11.858   (Pobrane:  2020-11-05)


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