	5.	Kertmen A., Przysiecka Ł., Coy E., Popenda Ł., Andruszkiewicz R., Jurga S., Milewski S.
	Abstrakt lub materiały konferencyjne, albo abstrakt publikacji z dodatkowymi numerami DOI	Correction: Emerging anticancer activity of candidal glucosamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery (vol 35, pg 5281, 2019) Corrections to the title and affiliations are reflected in this Addition & Correction
		Langmuir, 35(44), 14397-14397 (2019)
		DOI: 10.1021/acs.langmuir.9b03088 (Pobrane: 2020-12-30)

	4.	Kertmen A., Przysiecka Ł., Coy E., Popenda Ł., Andruszkiewicz R., Jurga S., Milewski S.
		Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery Numerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N-3-(4-methoxyfumaroy1)-L-2,3-diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide-FMDP conjugates were tested to deliver FMDP to its subcellularly located GIcN-6-P synthase target. However, the rapid development of fungal resistance to FMDP-peptides required development of different therapeutic approaches to tackle antifungal resistance. In the current state of the global antifungal resistance, subcellular delivery of FMDP via free diffusion or endocytosis has become crucial. In this study, we report on in vitro nanomedical applications of FMDP and one of its ketoacid analogues, N-3-trans-4-oxo-4-phenyl-2-butenoyl-L-2,3-diaminopropanoic acid (BADP). FMDP and BADP covalently attached to polyethylene glycol-coated iron oxide/silica core-shell nanoparticles are tested against intrinsically multidrug-resistant C. albicans. Three different human cancer cell lines potentially overexpressing the GlcN-6-P synthase enzyme are tested to demonstrate the immediate inhibitory effects of nanoparticle conjugates against mammalian cells. It is shown that nanoparticle-mediated delivery transforms FMDP and BADP into strong anticancer agents by inhibiting the growth of the tested cancer cells, whereas their anti-Candidal activity is decreased. This study discusses the emerging inhibitory effect of the FMDP/BADP-nanoparticle conjugates based on their cellular internalization efficiency and biocompatibility.
		Langmuir, 35(15), 5281-5293 (2019)
		DOI: 10.1021/acs.langmuir.8b04250 (Pobrane: 2020-12-30)

	3.	Kertmen A., Barbe E., Szkoda M., Siuzdak K., Babacic V., Torruella P., Iatsunskyi I., Kotkowiak M., Rytel K., Estrade S., Peiro F., Jurga S., Li Yanguang, Coy E.
		Photoelectrochemically active n-adsorbing ultrathin TiO2 layers for water-splitting applications prepared by pyrolysis of oleic acid on iron oxide nanoparticle surfaces under nitrogen environment Highly performing photocatalytic surfaces are nowadays highly desirable in energy fields, mainly due to their applicability as photo water-splitting electrodes. One of the current challenges in this field is the production of highly controllable and efficient photoactive surfaces on many substrates. Atomic layer deposition has allowed the deposition of photoactive TiO2 layers over wide range of materials and surfaces. However, nitrogen doping of the growing layers, a highly effective way of controlling the absorption edges of photoactive surfaced, is still a challenging task. Here, the preparation of hierarchical nanostructured surfaces based on Langmuir-Schaefer and atomic layer deposition is proposed. Ultrathin TiO2 layers that are photoelectrochemically active in water splitting are prepared by a relatively low-temperature catalytic decomposition of oleic acid capping layers of iron oxide nanoparticles and the posterior nitrogen adsorption. The results evidence that simple N-adsorption is sufficient to narrow the bandgap of TiO2 layers that is equal to bandgap narrowing (0.12 eV) observed for substitutionally N-doped materials. The photocatalytic activity tests of the prepared surfaces in water-splitting applications demonstrate approximate to 90% increase in the activity of the N-adsorbing TiO2 layers.
		Advanced Materials Interfaces, 6(3), 1801286 (2019)
		DOI: 10.1002/admi.201801286 (Pobrane: 2020-12-28)

	2.	Kertmen A., Torruella P., Coy E., Yate L., Nowaczyk G., Gapiński J., Vogt C., Toprak M., Estrade S., Peiro F., Milewski S., Jurga S., Andruszkiewicz R.
		Acetate-induced disassembly of spherical iron oxide nanoparticle clusters into monodispersed core-shell structures upon nanoemulsion fusion It has been long known that the physical encapsulation of oleic acid-capped iron oxide nanoparticles (OA-IONPs) with the cetyltrimethylammonium (CTA(+)) surfactant induces the formation of spherical iron oxide nanoparticle clusters (IONPCs). However, the behavior and functional properties of IONPCs in chemical reactions have been largely neglected and are still not well-understood. Herein, we report an unconventional ligand-exchange function of IONPCs activated when dispersed in an ethyl acetate/acetate buffer system. The ligand exchange can successfully transform hydrophobic OA-IONP building blocks of IONPCs into highly hydrophilic, acetate-capped iron oxide nanoparticles (Ac-IONPs). More importantly, we demonstrate that the addition of silica precursors (tetraethyl orthosilicate and 3-aminopropyltriethoxysilane) to the acetate/oleate ligand-exchange reaction of the IONPs induces the disassembly of the IONPCs into monodispersed iron oxide-acetate-silica core-shell-shell (IONPs@acetate@SiO2) nanoparticles. Our observations evidence that the formation of IONPs@acetate@SiO2 nanoparticles is initiated by a unique micellar fusion mechanism between the Pickering-type emulsions of IONPCs and nanoemulsions of silica precursors formed under ethyl acetate buffered conditions. A dynamic rearrangement of the CTA(+)-oleate bilayer on the IONPC surfaces is proposed to be responsible for the templating process of the silica shells around the individual IONPs. In comparison to previously reported methods in the literature, our work provides a much more detailed experimental evidence of the silica-coating mechanism in a nanoemulsion system. Overall, ethyl acetate is proven to be a very efficient agent for an effortless preparation of monodispersed IONPs@acetate@SiO2 and hydrophilic Ac-IONPs from IONPCs.
		Langmuir, 33(39), 10351-10365 (2017)
		DOI: 10.1021/acs.langmuir.7b02743 (Pobrane: 2018-03-20)

	1.	Tadyszak K., Kertmen A., Coy E., Andruszkiewicz R., Milewski S., Kardava I., Scheibe B., Jurga S., Chybczyńska K.
		Spectroscopic and magnetic studies of highly dispersible superparamagnetic silica coated magnetite nanoparticles Superparamagnetic behavior in aqueously well dispersible magnetite core-shell Fe3O4@SiO2 nanoparticles is presented. The magnetic properties of core-shell nanoparticles were measured with use of the DC, AC magnetometry and EPR spectroscopy. Particles where characterized by HR-TEM and Raman spectroscopy, showing a crystalline magnetic core of 11.5 ± 0.12 nm and an amorphous silica shell of 22 ± 1.5 nm in thickness. The DC, AC magnetic measurements confirmed the superparamagnetic nature of nanoparticles, additionally the EPR studies performed at much higher frequency than DC, AC magnetometry (9 GHz) have confirmed the paramagnetic nature of the nanoparticles. Our results show the excellent magnetic behavior of the particles with a clear magnetite structure, which are desirable properties for environmental remediation and biomedical applications.
		Journal of Magnetism and Magnetic Materials, 433, 254-261 (2017)
		DOI: 10.1016/j.jmmm.2017.03.025